can we detect Alzheimer's disease in our patients by a retinal exam.

A recent paper states:  The optimal excitation for curcumin bound to Aβ plaques was at 550 nm, with emission peaking at 605–610 nm (Fig. 5f). The optimal excitation for Cy5-Abs bound to anti-Aβ mAbs attached to Aβ plaques was 640 nm, with emission peaking at 675 nm (Fig. 5h). DAPI staining also had a distinct spectral pattern, as expected, given its optimal excitation/emission wavelengths of 365/445 nm. Spectral analysis of double-labeled individual plaques revealed separate emission peaks for each fluorochrome (similar to the single labeling) that could be distinctly captured by our selected filter sets (Fig. 5j; see Material and methods).

Our FA machines have filters around 610 for fluorescein imaging.  however their excitation filter is peaked around 450 nm.   Is it possible excite at 550 nm?

T​hat is excite below 575 nm or so so that we can separate the excitation and emission spectra?

Would any of you be able to find out if the Heidelberg or Ziess (or possibly the OPTOS) is able to do this?​

Thanks for any input!  If you want the pdf article I can post it here.

Stuart  

http://www.pnas.org/content/99/18/11830/F1.expansion.html

Seems the Alzeiheimers AB peptide can be found to be deposited in some pseudo drusen and have this interesting artists diagram [attached] to share with our cousins.

We are not currently investigating this in our office, but I share your enthusiasm.